Technique

DNA Damage Atlas

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Total Page: 4 Total entries: 69

Technique	Publication	Journal	Targets	Class
PEM-seq	PEM-seq comprehensively quantifies DNA repair outcomes during gene-editing and DSB repair	Star protocol	DSB	DNA damage
HTGTS	Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells	Cell	DSB	DNA damage
Break-seq	Break-seq reveals hydroxyurea-induced chromosome fragility as a result of unscheduled conflict between DNA replication and transcription	Genome Research	DSB	DNA damage
Protec-seq	Spo11 generates gaps through concerted cuts at sites of topological stress	Science	dDSB	DNA damage
CC-seq	A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome	Nature Communications	Spo11cc/TOP2cc	DNA damage responses or repair intermediate
SPO11-oligo	The Landscape of Mouse Meiotic Double-Strand Break Formation, Processing, and Repair	Cell	Spo11-oligo	DNA damage responses or repair intermediate
DMC1/Rad51 SSDS	Sensitive mapping of recombination hotspots using sequencing-based detection of ssDNA	Genome Research	DMC1/Rad51	DNA damage responses or repair intermediate
RPA/911 ChIP-seq	Strand-specific ChIP-seq at DNA breaks distinguishes ssDNA versus dsDNA binding and refutes single-stranded nucleosomes	Molecular Cell	RPA/911	DNA damage responses or repair intermediate
DISCOVER-seq	Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq	Science	MRE11	DNA damage responses or repair intermediate
FANCD2/Ku/Rad50 ChIP-seq	Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq	Science	FANCD2/Ku/Rad50	DNA damage responses or repair intermediate
MRE11 ChIP-seq	ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis	Nature Communications	MRE11	DNA damage responses or repair intermediate
gH2AX ChIP-seq	High-resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome	EMBO Journal	gH2AX	DNA damage responses or repair intermediate
PAR ChIP-seq	Neuronal enhancers are hotspots for DNA single-strand break repair	Nature	PAR	DNA damage responses or repair intermediate
XRCC1 ChIP-seq	Neuronal enhancers are hotspots for DNA single-strand break repair	Nature	XRCC1	DNA damage responses or repair intermediate
53BP1/Lig4 ChIP-seq	Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures	Molecular Cell	53BP1/Lig4	DNA damage responses or repair intermediate
TCR-seq	Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair	Cell	RNAPII	DNA damage responses or repair intermediate
RAD51/XRCC4 ChIP-seq	Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks	Nature Structural & Molecular Biology	RAD51/XRCC4	DNA damage responses or repair intermediate
MiDAS	Genome-wide high-resolution mapping of mitotic DNA synthesis sites and common fragile sites by direct sequencing	Cell Research	mitotic DNA synthesis	DNA damage responses or repair intermediate
BrdU-seq	Persistence of RNA transcription during DNA replication delays duplication of transcription start sites until G2/M	Cell Reports	DNA repair synthesis	DNA damage responses or repair intermediate
SAR-seq	Neuronal enhancers are hotspots for DNA single-strand break repair	Nature	DNA repair synthesis	DNA damage responses or repair intermediate

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